Article
Estimating heritability in pharmacogenetic studies.
Pharmacogenomics - 1 Mar 2013
Marshall Scott L, Guennel Tobias, Kohler Jared, Man Michael, Fossceco Stewart
Abstract excerpt
AIM: This article aims to evaluate the performance of a recent method to estimate heritability of continuous and binary traits, specifically in the context of pharmacogenetic studies. MATERIALS & METHODS: The approach to be evaluated was designed to estimate heritability in large-scale disease studies. Extensive simulation studies designed to emulate common scenarios seen in pharmacogenetic studies were performed...
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