Article
Surviving Fibroblasts After Treatment With Mitomycin C Exhibit SASP-Like Phenotype After Glaucoma Filtration Surgery.
Aging cell - 1 Sept 2026
Kimura Akitoshi, Fujimoto Tomokazu, Iraha Satoshi, Yasunaga Kei-Ichiro, Inoue-Mochita Miyuki, Funagura Naofumi, Tanigawa Shunsuke, Kurotaki Daisuke, Koga Tomoaki, Watanabe-Kitamura Fumika, Tsutsumi-Kuroda Utako, Nakao Mitsuyoshi, Inoue Toshihiro
Abstract excerpt
The clinical outcomes of trabeculectomy, a standard glaucoma filtration surgery (GFS), have dramatically improved with the introduction of mitomycin C (MMC), an antimetabolite widely used to inhibit postoperative scarring. MMC exerts anti-scarring effects primarily by promoting apoptosis and suppressing fibroblast proliferation at the surgical site. However, despite these beneficial effects, MMC also induces the...
Read the complete abstract on PubMedTopics
Share this publication in a Topic to start or enrich a Post.