Article
LegC3, an effector protein from Legionella pneumophila, inhibits homotypic yeast vacuole fusion in vivo and in vitro.
PloS one - 1 Jan 2013
Bennett Terry L, Kraft Shannon M, Reaves Barbara J, Mima Joji, O'Brien Kevin M, Starai Vincent J
Abstract excerpt
During infection, the intracellular pathogenic bacterium Legionella pneumophila causes an extensive remodeling of host membrane trafficking pathways, both in the construction of a replication-competent vacuole comprised of ER-derived vesicles and plasma membrane components, and in the inhibition of normal phagosome:endosome/lysosome fusion pathways. Here, we identify the LegC3 secreted effector protein from L....
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