Article
Ectopic expression of Ptf1a induces spinal defects, urogenital defects, and anorectal malformations in Danforth's short tail mice.
PLoS genetics - 1 Jan 2013
Semba Kei, Araki Kimi, Matsumoto Ken-ichirou, Suda Hiroko, Ando Takashi, Sei Akira, Mizuta Hiroshi, Takagi Katsumasa, Nakahara Mai, Muta Mayumi, Yamada Gen, Nakagata Naomi, Iida Aritoshi, Ikegawa Shiro, Nakamura Yusuke, Araki Masatake, Abe Kuniya, Yamamura Ken-ichi
Abstract excerpt
Danforth's short tail (Sd) is a semidominant mutation on mouse chromosome 2, characterized by spinal defects, urogenital defects, and anorectal malformations. However, the gene responsible for the Sd phenotype was unknown. In this study, we identified the molecular basis of the Sd mutation. By positional cloning, we identified the insertion of an early transposon in the Sd candidate locus approximately 12-kb...
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