Article
Glial-cell-mediated re-induction of the blood-brain barrier phenotype in brain capillary endothelial cells: a differential gel electrophoresis study.
Proteomics - 1 Apr 2013
Deracinois Barbara, Pottiez Gwënaël, Chafey Philippe, Teerlink Tom, Camoin Luc, Davids Mariska, Broussard Cédric, Couraud Pierre-Olivier, Dehouck Marie-Pierre, Cecchelli Roméo, Karamanos Yannis, Flahaut Christophe
Abstract excerpt
In the neurovascular unit, brain microvascular endothelial cells develop characteristic barrier features that control the molecular exchanges between the blood and the brain. These characteristics are partially or totally lost when the cells are isolated for use in in vitro blood-brain barrier (BBB) models. Hence, the re-induction of barrier properties is crucial for the relevance of BBB models. Although the role...
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