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Article

Association of P2X7R gene polymorphisms with systemic lupus erythematosus in a Chinese population.

Mutagenesis - 1 May 2013

Chen Gui-Mei, Feng Chen-Chen, Ye Qian-Ling, Tao Jin-hui, Li Rui, Peng Hui, Zhou Mo, Leng Rui-Xue, Li Jing, Cen Han, Fan Yin-Guang, Pan Hai-Feng, Ye Dong-Qing

Abstract excerpt

The P2X7 receptor is a ligand-gated cationic channel receptor that is actived by ATP and normally expressed by a variety of immune system cells, including macrophages and lymphocytes. Because it leads to release of IL-1β and cell death by apoptosis or necrosis, it is a potential therapeutic target for a variety of autoimmune inflammatory diseases, such as systemic lupus erythematosus (SLE). The P2X7R gene is...

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PMID: 23435013
DOI: 10.1093/mutage/get007

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-07.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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