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Article

Identification of an oncogenic RAB protein.

Science (New York, N.Y.) - 9 Oct 2015

Wheeler Douglas B, Zoncu Roberto, Root David E, Sabatini David M, Sawyers Charles L

Abstract excerpt

In a short hairpin RNA screen for genes that affect AKT phosphorylation, we identified the RAB35 small guanosine triphosphatase (GTPase)-a protein previously implicated in endomembrane trafficking-as a regulator of the phosphatidylinositol 3'-OH kinase (PI3K) pathway. Depletion of RAB35 suppresses AKT phosphorylation in response to growth factors, whereas expression of a dominant active GTPase-deficient mutant of...

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Source

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Identifiers

PMID: 26338797
DOI: 10.1126/science.aaa4903
PMCID: PMC4600465

Genes

RAB35
LAMP2
PDK1

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 6 Sept 2026. Manifest publication-graph-cohort-2026-09-06.1.

Source receipt: pubmed, retrieved 6 Sept 2026.

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