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Article

Arginine homozygosity in codon 72 of p53 correlates with failure to imatinib response in chronic myeloid leukemia.

Biomedicine & pharmacotherapy = Biomedecine & pharmacotherapie - 1 Mar 2013

Camelo-Santos Jeany, do Prado Barbosa Adriana, de Paula Silveira-Lacerda Elisangela, Guillo Lidia Andreu

Abstract excerpt

PURPOSE: In this study, the role of the polymorphism at codon 72 of tumor protein p53 gene (TP53) was investigated regarding the response to treatment with imatinib in chronic myeloid leukemia (CML). METHODS: A total of 85 patients with CML were treated according to the Brazilian National Cancer Institute (INCA) guidelines and at the end of the 18th month a blood sample were collected for genotyping. Genomic DNA...

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PMID: 23433851
DOI: 10.1016/j.biopha.2012.11.004

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-07.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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