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Article

OCT4 increases BIRC5 and CCND1 expression and promotes cancer progression in hepatocellular carcinoma

22 Feb 2013

Abstract excerpt

BACKGROUND: OCT4 and BIRC5 are preferentially expressed in human cancer cells and mediate cancer cell survival and tumor maintenance. However, the molecular mechanism that regulates OCT4 and BIRC5 expression is not well characterized. METHODS: By manipulating OCT4 and BIRC5 expression in hepatocellular carcinoma (HCC) cell lines, the regulatory mechanism of OCT4 on BIRC5 and CCND1 were investigated. RESULTS:...

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PMID: 23433354
DOI: 10.1186/1471-2407-13-82

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