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BIRC6 promotes hepatocellular carcinogenesis: Interaction of BIRC 6 with p53 facilitating p53 degradation

6 Sept 2014

Abstract excerpt

The genes that encode inhibitor of apoptosis proteins (IAPs) are frequently overexpressed in human cancers. However, the expression pattern and clinical significance of BIRC6, a member of IAPs, in hepatocellular carcinoma (HCC) remains unclear. Here we investigated the role of BIRC6 in hepatocellular carcinogenesis. We used immunoblot and immunochemical analyses to determine the levels of BIRC6 in 7 hepatoma cell...

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PMID: 25196217
DOI: 10.1002/ijc.29194

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