Article
The A736V TMPRSS6 polymorphism influences hepcidin and iron metabolism in chronic hemodialysis patients: TMPRSS6 and hepcidin in hemodialysis.
BMC nephrology - 22 Feb 2013
Pelusi Serena, Girelli Domenico, Rametta Raffaela, Campostrini Natascia, Alfieri Carlo, Traglia Michela, Dongiovanni Paola, Como Giovanna, Toniolo Daniela, Camaschella Clara, Messa Piergiorgio, Fargion Silvia, Valenti Luca
Abstract excerpt
BACKGROUND: Aim of this study was to evaluate whether the A736V TMPRSS6 polymorphism, a major genetic determinant of iron metabolism in healthy subjects, influences serum levels of hepcidin, the hormone regulating iron metabolism, and erythropoiesis in chronic hemodialysis (CHD). METHODS: To this end, we considered 199 CHD patients from Northern Italy (157 with hepcidin evaluation), and 188 healthy controls...
Read the complete abstract on PubMedTopics
Share this publication in a Topic to start or enrich a Post.