Article
ETHNOPRED: a novel machine learning method for accurate continental and sub-continental ancestry identification and population stratification correction.
BMC bioinformatics - 22 Feb 2013
Hajiloo Mohsen, Sapkota Yadav, Mackey John R, Robson Paula, Greiner Russell, Damaraju Sambasivarao
Abstract excerpt
BACKGROUND: Population stratification is a systematic difference in allele frequencies between subpopulations. This can lead to spurious association findings in the case-control genome wide association studies (GWASs) used to identify single nucleotide polymorphisms (SNPs) associated with disease-linked phenotypes. Methods such as self-declared ancestry, ancestry informative markers, genomic control, structured...
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