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Effects of ciprofloxacin on the expression and production of exotoxins by Clostridium difficile

22 Feb 2013

Abstract excerpt

Hypervirulent BI/NAP1/027 strains of Clostridium difficile have been associated with increased mortality of C. difficile infection (CDI). The emergence of highly fluoroquinolone (FLQ)-resistant BI/NAP1/027 strains suggests that FLQ exposure may be a risk factor for CDI development. However, the mechanism for this is not clear. We compared the effects of subinhibitory concentrations of ciprofloxacin on Toxin A and...

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PMID: 23429695
DOI: 10.1099/jmm.0.056218-0

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