Discover Community Create You

Loading publication...

Noodle always counts identifier-free feature events for service operation. With your permission, Google Analytics can also estimate audience and engagement. Search text, publication identifiers, cookies, IP addresses and browser fingerprints are never included in Noodle's first-party event counters.

Privacy details

Article

Expression of the α-tocopherol transfer protein gene is regulated by oxidative stress and common single-nucleotide polymorphisms.

Free radical biology & medicine - 15 Dec 2012

Ulatowski Lynn, Dreussi Cara, Noy Noa, Barnholtz-Sloan Jill, Klein Eric, Manor Danny

Abstract excerpt

Vitamin E (α-tocopherol) is the major lipid-soluble antioxidant in most animal species. By controlling the secretion of vitamin E from the liver, the α-tocopherol transfer protein regulates whole-body distribution and levels of this vital nutrient. However, the mechanism(s) that regulates the expression of this protein is poorly understood. Here we report that transcription of the TTPA gene in immortalized human...

Read the complete abstract on PubMed

Topics

Share this publication in a Topic to start or enrich a Post.

Share to Binding Sites
Share to Carrier Proteins

Methodology Data sources Editorial policy Privacy Delete account & data About Contact Helena Bioinformatics

Share to Cyclic AMP Response Element-Binding Protein

Share to Organ Specificity

Share to Oxidative Stress

Share to Transcription, Genetic

Share to Transcriptional Activation

Source

Open in PubMed Open full text

Identifiers

PMID: 23079030
DOI: 10.1016/j.freeradbiomed.2012.10.528
PMCID: PMC3612136

Genes

TTPA

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-08.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

Related research

Semantic proximity does not establish scientific evidence. Graph snapshot: 2026-09-29.

Research trail→

Click a neighbor to travelStep 1 · 12 closest

Expression of the α-tocopherol transfer protein gene is regulated by oxidative stress and common single-nucleotide polymorphisms.PMID 23079030Read ↗

Gene-regulatory activity of alpha-tocopherol.Semantic proximity Read ↗

Localization of α-Tocopherol Transfer Protein in Trophoblast, Fetal Capillaries' Endothelium and Amnion Epithelium of Human Term PlacentaSemantic proximity Read ↗

Biochemical consequences of heritable mutations in the alpha-tocopherol transfer protein.Semantic proximity Read ↗

α-Tocopherol Transfer Protein Is Important for the Normal Development of Placental Labyrinthine Trophoblasts in MiceSemantic proximity Read ↗

Regulation of the gene encoding human thrombin-activatable fibrinolysis inhibitor by estrogen and progesterone.Semantic proximity Read ↗

Ataxia caused by mutations in the alpha-tocopherol transfer protein gene.Semantic proximity Read ↗

The transcriptional coactivator PGC-1 regulates the expression and activity of the orphan nuclear receptor estrogen-related receptor alpha (ERRalpha).Semantic proximity Read ↗

In silico search for single nucleotide polymorphisms in genes important in vitamin E homeostasis.Semantic proximity Read ↗

Ataxia with isolated vitamin E deficiency is caused by mutations in the alpha-tocopherol transfer protein.Semantic proximity Read ↗

Genetic Variations Involved in Vitamin E Status.Semantic proximity Read ↗

Vitamin E and Phosphoinositides Regulate the Intracellular Localization of the Hepatic α-Tocopherol Transfer Protein.Semantic proximity Read ↗

Intronic SNP rs3811647 of the human transferrin gene modulates its expression in hepatoma cells.Semantic proximity Read ↗

⌁Select a neighboring publication to make it the new centre.