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Article

GxE effects of FKBP5 and traumatic life events on PTSD: A meta-analysis.

Journal of affective disorders - 15 Jan 2019

Hawn Sage E, Sheerin Christina M, Lind Mackenzie J, Hicks Terrell A, Marraccini Marisa E, Bountress Kaitlin, Bacanu Silviu-Alin, Nugent Nicole R, Amstadter Ananda B

Abstract excerpt

BACKGROUND: Twin studies have demonstrated that both genetic and environmental factors influence risk for posttraumatic stress disorder (PTSD), and there is some evidence supporting the interplay of genes and environment (GxE). Many GxE studies within the PTSD literature have focused on genes implicated in the stress response system, such as FK506 binding protein 51 (FKBP5). Given inconsistencies across GxE...

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Topics

Gene-Environment Interaction
Genetic Predisposition to Disease
Humans
Stress Disorders, Post-Traumatic
Tacrolimus Binding Proteins

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Source

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Identifiers

PMID: 30273884
DOI: 10.1016/j.jad.2018.09.058
PMCID: PMC6487483

Genes

FKBP5

Provenance

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