[Association of tumor necrosis factor-alpha gene polymorphisms with Henoch-Schonlein purpura nephritis in children].

Abstract excerpt

OBJECTIVE: To study the relationship of tumor necrosis factor-alpha (TNF-α)-308G/A gene polymorphisms with Henoch-Schonlein purpura nephritis (HSPN) in children. METHODS: Using the direct DNA sequencing method, polymorphisms in the TNF-α promoter region (-308) were genotyped in 110 Han children with Henoch-Schonlein purpura (HSP group), including 52 children with nephritis and 58 children without nephritis....

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