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Article

Identification of two mutation sites in spike and envelope proteins mediating optimal cellular infection of porcine epidemic diarrhea virus from different pathways.

Veterinary research - 30 Aug 2017

Sun Min, Ma Jiale, Yu Zeyanqiu, Pan Zihao, Lu Chengping, Yao Huochun

Abstract excerpt

Entry of the α-coronavirus porcine epidemic diarrhea virus (PEDV) requires specific proteases to activate spike (S) protein for the membrane fusion of the virion to the host cell following receptor binding. Herein, PEDV isolate 85-7 could proliferate and induce cell-cell fusion in a trypsin independent manner on Vero cells, and eight homologous mutation strains were screened by continuous proliferation in the...

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Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

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Identifiers

PMID: 28854955
DOI: 10.1186/s13567-017-0449-y
PMCID: PMC5577753

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