ROS1-fusion protein induces PD-L1 expression via MEK-ERK activation in non-small cell lung cancer

Abstract excerpt

Introduction Despite some of the oncogenic driver mutations that have been associated with increased expression of programmed death-ligand 1 (PD-L1), the correlation between PD-L1 expression and ROS1 fusion in NSCLC cells, especially for those with Crizotinib resistance has not been fully addressed.Materials and Methods The expression of PD-L1 in 30 primary NSCLC tumors with/without ROS1-fusion protein was...

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