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Article

Accelerated cell aging in female APOE-ε4 carriers: implications for hormone therapy use.

PloS one - 1 Jan 2013

Jacobs Emily G, Kroenke Candyce, Lin Jue, Epel Elissa S, Kenna Heather A, Blackburn Elizabeth H, Rasgon Natalie L

Abstract excerpt

Apolipoprotein-ε4 (APOE-ε4) is a major genetic risk factor for cognitive decline, Alzheimer's disease (AD) and early mortality. An accelerated rate of biological aging could contribute to this increased risk. Here, we determined whether APOE-ε4 status impacts leukocyte telomere length (TL) and the rate of cellular senescence in healthy mid-life women and, further, whether hormone replacement therapy (HT) modifies...

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Source

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Identifiers

PMID: 23418430
DOI: 10.1371/journal.pone.0054713
PMCID: PMC3572118

Genes

APOE

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-08.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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