Article
Targeted metabolic engineering guided by computational analysis of single-nucleotide polymorphisms (SNPs).
Methods in molecular biology (Clifton, N.J.) - 1 Jan 2013
Udatha D B R K Gupta, Rasmussen Simon, Sicheritz-Pontén Thomas, Panagiotou Gianni
Abstract excerpt
The non-synonymous SNPs, the so-called non-silent SNPs, which are single-nucleotide variations in the coding regions that give "birth" to amino acid mutations, are often involved in the modulation of protein function. Understanding the effect of individual amino acid mutations on a protein/enzyme function or stability is useful for altering its properties for a wide variety of engineering studies. Since measuring...
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