Lynch syndrome: clinical, pathological, and genetic insights.

Abstract excerpt

INTRODUCTION: Lynch syndrome as the most common hereditary colorectal cancer syndrome and the most common cause of hereditary endometrial cancer is characterized by an autosomal dominant inheritance with a penetrance of 85-90%. The molecular genetic underlying mechanism is a mutation in one of the mismatch repair genes. METHODS: In order to identify patients with Lynch syndrome, a nuclear family history should be...

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