Article
Short-term, high fat feeding-induced changes in white adipose tissue gene expression are highly predictive for long-term changes.
Molecular nutrition & food research - 1 Aug 2013
Voigt Anja, Agnew Katrin, van Schothorst Evert M, Keijer Jaap, Klaus Susanne
Abstract excerpt
SCOPE: We aimed to evaluate the predictability of short-term (5 days) changes in epididymal white adipose tissue (eWAT) gene expression for long-term (12 weeks) changes induced by high-fat diet (HFD) feeding. METHODS AND RESULTS: Mice were fed semisynthetic diets containing 10 (low-fat diet) or 40 (HFD) energy% of fat. Global gene expression in eWAT was analyzed using microarrays and confirmed by quantitative...
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