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Article

Gene set of nuclear-encoded mitochondrial regulators is enriched for common inherited variation in obesity.

PloS one - 1 Jan 2013

Knoll Nadja, Jarick Ivonne, Volckmar Anna-Lena, Klingenspor Martin, Illig Thomas, Grallert Harald, Gieger Christian, Wichmann Heinz-Erich, Peters Annette, Hebebrand Johannes, Scherag André, Hinney Anke

Abstract excerpt

There are hints of an altered mitochondrial function in obesity. Nuclear-encoded genes are relevant for mitochondrial function (3 gene sets of known relevant pathways: (1) 16 nuclear regulators of mitochondrial genes, (2) 91 genes for oxidative phosphorylation and (3) 966 nuclear-encoded mitochondrial genes). Gene set enrichment analysis (GSEA) showed no association with type 2 diabetes mellitus in these gene...

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PMID: 23409076
DOI: 10.1371/journal.pone.0055884
PMCID: PMC3568071

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