Article
Genetic polymorphisms of Fas (CD95) and Fas ligand (CD178) influence the rise in CD4+ T cell count after antiretroviral therapy in drug-naïve HIV-positive patients.
Immunogenetics - 1 Oct 2005
Nasi Milena, Pinti Marcello, Bugarini Roberto, Troiano Leonarda, Lugli Enrico, Bellodi Cristian, Mussini Cristina, Borghi Vanni, Trenti Tommaso, Balli Fiorella, Esposito Roberto, Cossarizza Andrea
Abstract excerpt
Fas and Fas ligand (FasL) are the main genes that control cell death in the immune system. Indeed, they are crucial for the regulation of T lymphocyte homeostasis because they can influence cell proliferation. A strong debate exists on the importance of Fas/FasL system during HIV infection, which is characterized by the loss of CD4+ T cells directly, or indirectly, caused by the virus. To investigate whether the...
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