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Article

Implementation of universal microsatellite instability and immunohistochemistry screening for diagnosing lynch syndrome in a large academic medical center.

Journal of clinical oncology : official journal of the American Society of Clinical Oncology - 1 Apr 2013

Heald Brandie, Plesec Thomas, Liu Xiuli, Pai Rish, Patil Deepa, Moline Jessica, Sharp Richard R, Burke Carol A, Kalady Matthew F, Church James, Eng Charis

Abstract excerpt

PURPOSE: In 2009, the Evaluation of Genomic Applications in Practice and Prevention recommended that all colorectal cancers (CRCs) be screened for Lynch syndrome (LS) through microsatellite instability (MSI) or immunohistochemistry (IHC). No studies report how this process is implemented on a health system-wide basis. METHODS: Since 2004, Cleveland Clinic has screened CRC specimens with MSI/IHC. Between January...

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Source

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Identifiers

PMID: 23401454
DOI: 10.1200/JCO.2012.45.1674
PMCID: PMC4878100

Genes

BRAF
MLH1

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 6 Sept 2026. Manifest publication-graph-cohort-2026-09-06.1.

Source receipt: pubmed, retrieved 6 Sept 2026.

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