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Article

Refinement of a DNA based Alzheimer disease epitope vaccine in rabbits

5 Apr 2013

Abstract excerpt

We previously demonstrated that our second-generation DNA-based Alzheimer disease (AD) epitope vaccine comprising three copies of a short amyloid-β (Aβ) B cell epitope, Aβ 11 fused with the foreign promiscuous Th epitope, PADRE (p3Aβ 11-PADRE) was immunogenic in mice. However, since DNA vaccines exhibit poor immunogenicity in large animals and humans, in this study, we sought to improve the immunogenicity of p3Aβ...

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PMID: 23399748
DOI: 10.4161/hv.23875

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