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Article

I32E and V36K double mutation in beta2-sheet abrogates amyloid beta peptide toxicity.

Indian journal of experimental biology - 1 Nov 2010

Subramanian Sarada, Mishra Pradeep Kumar, Bandopadhyay Debashree

Abstract excerpt

Alzheimer's disease (AD) is the most common cause of dementia in the elderly, wherein, the accumulation of amyloid beta (Abeta) peptide as cytotoxic oligomers leads to neuropathologic changes. Transgenic mice with brain Abeta plaques immunized with aggregated Abeta have reduced amyloid burden and improved cognitive functions. However, such active immunization in humans led to a small but significant occurrence of...

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PMID: 21117449

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-07.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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