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Article

Direct detection of beta thalassemic mutations: use of biotin-labelled allele specific probes.

American journal of hematology - 1 Jun 1990

Hendy J G, Cauchi M N

Abstract excerpt

Mutations at positions beta IVS1-6, beta IVS1-110, and beta 39 of the beta globin gene are responsible for the three most common thalassemic genes in the Mediterranean population. The polymerase chain reaction (PCR) was employed to amplify a 536 base pair segment surrounding this region. Nonradioactive labelling of an oligonucleotide probe, specific for the beta IVS1-110 mutation, was achieved by incorporation of...

Topics

Alleles
Biotin
Child
Genetic Markers
Homozygote
Humans
Mutation
Thalassemia

Source

Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

Identifiers

PMID: 2339680
DOI: 10.1002/ajh.2830340213

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 29 Aug 2026. Prepared record publication-2339680-2026-08-29.1. Manifest publication-graph-cohort-2026-08-29.1.

Source receipt: PubMed via Helena Literature Corpus, retrieved 29 Aug 2026.

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Direct detection of beta thalassemic mutations: use of biotin-labelled allele specific probes.PMID 2339680Read ↗

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