Article
Beta-thalassemia in Bulgaria.
Hemoglobin - 1 Jan 1990
Petkov G H, Efremov G D, Efremov D G, Dimovski A, Tchaicarova P, Tchaicarov R, Rogina B, Agarwal S, Kutlar A, Kutlar F
Abstract excerpt
Analyses of DNA from 64 patients with thalassemia major using the hybridization technique of amplified DNA with radiolabeled synthetic oligonucleotide probes identified 13 different beta-thalassemia mutations. The codon 39 (C----T) and IVS-I-110 (G----A) mutations occurred most frequently but sev...
Topics
- Adolescent
- Adult
- Alleles
- Bulgaria
- Child
- Child, Preschool
- DNA Mutational Analysis
- Female
- Gene Frequency
- Genotype
- Globins
- Hemoglobinopathies
- Hemoglobins, Abnormal
- Humans
- Male
- Promoter Regions, Genetic
- Thalassemia