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Article

Rhamnogalacturonan II is a Toll-like receptor 4 agonist that inhibits tumor growth by activating dendritic cell-mediated CD8+ T cells.

Experimental & molecular medicine - 8 Feb 2013

Park Sung Nam, Noh Kyung Tae, Jeong Young-Il, Jung In Duk, Kang Hyun Kyu, Cha Gil Sun, Lee Su Jung, Seo Jong Keun, Kang Dae Hwan, Hwang Tae-Ho, Lee Eun Kyung, Kwon Byungsuk, Park Yeong-Min

Abstract excerpt

We evaluated the effectiveness of rhamnogalacturonan II (RG-II)-stimulated bone marrow-derived dendritic cells (BMDCs) vaccination on the induction of antitumor immunity in a mouse lymphoma model using EG7-lymphoma cells expressing ovalbumin (OVA). BMDCs treated with RG-II had an activated phenotype. RG-II induced interleukin (IL)-12, IL-1β, tumor necrosis factor-α (TNF-α) and interferon-γ (IFN-γ) production...

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Identifiers

PMID: 23392255
DOI: 10.1038/emm.2013.14
PMCID: PMC3584663

Genes

TLR4
TNF

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 5 Sept 2026. Manifest publication-graph-cohort-2026-09-05.1.

Source receipt: pubmed, retrieved 5 Sept 2026.

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