Article
Crohn's disease loci are common targets of protozoa-driven selection.
Molecular biology and evolution - 1 May 2013
Cagliani Rachele, Pozzoli Uberto, Forni Diego, Cassinotti Andrea, Fumagalli Matteo, Giani Matteo, Fichera Maria, Lombardini Marta, Ardizzone Sandro, Asselta Rosanna, de Franchis Roberto, Riva Stefania, Biasin Mara, Comi Giacomo P, Bresolin Nereo, Clerici Mario, Sironi Manuela
Abstract excerpt
Previous studies indicated that a few risk variants for autoimmune diseases are subject to pathogen-driven selection. Nonetheless, the proportion of risk loci that has been targeted by pathogens and the type of infectious agent(s) that exerted the strongest pressure remain to be evaluated. We assessed whether different pathogens exerted a pressure on known Crohn's disease (CD) risk variants and demonstrate that...
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