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Article

Molecular bases of defective signal transduction in the platelet P2Y <sub>12</sub> receptor of a patient with congenital bleeding

10 Feb 2003

Abstract excerpt

We have identified structural attributes required for signal transduction through a seven-transmembrane-domain receptor. Platelets from a patient (AC) with a congenital bleeding disorder had normal shape change but reduced and reversible aggregation in response to 4 microM ADP, similar to normal platelets with blocked P2Y(12) receptor. The response to 20 microM ADP, albeit still decreased, was more pronounced and...

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PMID: 12578987
DOI: 10.1073/pnas.0437879100

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