Discover Community Create You

Loading publication...

Noodle always counts identifier-free feature events for service operation. With your permission, Google Analytics can also estimate audience and engagement. Search text, publication identifiers, cookies, IP addresses and browser fingerprints are never included in Noodle's first-party event counters.

Privacy details

Article

Foxa1 and Foxa2 are required for formation of the intervertebral discs.

PloS one - 1 Jan 2013

Maier Jennifer A, Lo YinTing, Harfe Brian D

Abstract excerpt

The intervertebral disc (IVD) is composed of 3 main structures, the collagenous annulus fibrosus (AF), which surrounds the gel-like nucleus pulposus (NP), and hyaline cartilage endplates, which are attached to the vertebral bodies. An IVD is located between each vertebral body. Degeneration of the IVD is thought to be a major cause of back pain, a potentially chronic condition for which there exist few effective...

Read the complete abstract on PubMed

Topics

Share this publication in a Topic to start or enrich a Post.

Share to Brachyury Protein
Share to Fetal Proteins
Share to Hepatocyte Nuclear Factor 3-alpha

Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

Share to Hepatocyte Nuclear Factor 3-beta

Share to Intervertebral Disc

Share to Neural Tube

Share to Notochord

Share to Organogenesis

Source

Open in PubMed Open full text

Identifiers

PMID: 23383217
DOI: 10.1371/journal.pone.0055528
PMCID: PMC3561292

Genes

IVD

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-07.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

Related research

Semantic proximity does not establish scientific evidence.

Research trail→

Click a neighbor to travelStep 1 · 12 closest

Foxa1 and Foxa2 are required for formation of the intervertebral discs.PMID 23383217Read ↗

Shh signaling from the nucleus pulposus is required for the postnatal growth and differentiation of the mouse intervertebral disc.Semantic proximity Read ↗

Transformation of resident notochord‐descendent nucleus pulposus cells in mouse injury‐induced fibrotic intervertebral discsSemantic proximity Read ↗

Tracing notochord-derived cells using a <i>Noto-cre</i> mouse: implications for intervertebral disc developmentSemantic proximity Read ↗

Avian intervertebral disc arises from rostral sclerotome and lacks a nucleus pulposus: Implications for evolution of the vertebrate discSemantic proximity Read ↗

Getting to the Core: Exploring the Embryonic Development from Notochord to Nucleus PulposusSemantic proximity Read ↗

Sonic hedgehog in the notochord is sufficient for patterning of the intervertebral discs.Semantic proximity Read ↗

Derivation of notochordal cells from human embryonic stem cells reveals unique regulatory networks by single cell‐transcriptomicsSemantic proximity Read ↗

Developmental mechanisms of intervertebral disc and vertebral column formationSemantic proximity Read ↗

Intervertebral disc-intrinsic Hedgehog signaling maintains disc cell phenotypes and prevents disc degeneration through both cell autonomous and non-autonomous mechanisms.Semantic proximity Read ↗

Coming together is a beginning: The making of an intervertebral discSemantic proximity Read ↗

Molecular profiling of the developing mouse axial skeleton: a role for Tgfbr2 in the development of the intervertebral discSemantic proximity Read ↗

The transcription factors regulating intervertebral disc developmentSemantic proximity Read ↗

⌁Select a neighboring publication to make it the new centre.