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Article

Sonic hedgehog in the notochord is sufficient for patterning of the intervertebral discs.

Mechanisms of development - 1 Jan 2000

Choi Kyung-Suk, Lee Chanmi, Harfe Brian D

Abstract excerpt

The intervertebral discs, located between adjacent vertebrae, are required for stability of the spine and distributing mechanical load throughout the vertebral column. All cell types located in the middle regions of the discs, called nuclei pulposi, are derived from the embryonic notochord. Recently, it was shown that the hedgehog signaling pathway plays an essential role during formation of nuclei pulposi....

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Source

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Identifiers

PMID: 22841806
DOI: 10.1016/j.mod.2012.07.003
PMCID: PMC3478436

Genes

SHH

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 4 Sept 2026.

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Sonic hedgehog in the notochord is sufficient for patterning of the intervertebral discs.PMID 22841806Read ↗

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Notochord-dependent expression of MFH1 and PAX1 cooperates to maintain the proliferation of sclerotome cells during the vertebral column development.Semantic proximity Read ↗

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