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Article

Tracing notochord-derived cells using a <i>Noto-cre</i> mouse: implications for intervertebral disc development

26 Oct 2011

Abstract excerpt

Back pain related to intervertebral disc degeneration is the most common musculoskeletal problem, with a lifetime prevalence of 82%. The lack of effective treatment for this widespread problem is directly related to our limited understanding of disc development, maintenance and degeneration. The aim of this study was to determine the developmental origins of nucleus pulposus cells within the intervertebral disc...

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PMID: 22028328
DOI: 10.1242/dmm.008128

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Related research

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Tracing notochord-derived cells using a <i>Noto-cre</i> mouse: implications for intervertebral disc developmentPMID 22028328Read ↗

Toward an understanding of the role of notochordal cells in the adult intervertebral disc: From discord to accordSemantic proximity Read ↗

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Notochordal Cell-Based Treatment Strategies and Their Potential in Intervertebral Disc RegenerationSemantic proximity Read ↗

Derivation of notochordal cells from human embryonic stem cells reveals unique regulatory networks by single cell‐transcriptomicsSemantic proximity Read ↗

Getting to the Core: Exploring the Embryonic Development from Notochord to Nucleus PulposusSemantic proximity Read ↗

An understanding of intervertebral disc development, maturation and cell phenotype provides clues to direct cell-based tissue regeneration therapies for disc degeneration.Semantic proximity Read ↗

Foxa1 and Foxa2 are required for formation of the intervertebral discs.Semantic proximity Read ↗

Leptin receptor–expressing cells represent a distinct subpopulation of notochord-derived cells and are essential for disc homoeostasisSemantic proximity Read ↗

Avian intervertebral disc arises from rostral sclerotome and lacks a nucleus pulposus: Implications for evolution of the vertebrate discSemantic proximity Read ↗

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