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Article

Comparative genomic analysis of East Asian and non-Asian Helicobacter pylori strains identifies rapidly evolving genes.

PloS one - 1 Jan 2013

Duncan Stacy S, Valk Pieter L, McClain Mark S, Shaffer Carrie L, Metcalf Jason A, Bordenstein Seth R, Cover Timothy L

Abstract excerpt

Helicobacter pylori infection is a risk factor for the development of gastric adenocarcinoma, a disease that has a high incidence in East Asia. Genes that are highly divergent in East Asian H. pylori strains compared to non-Asian strains are predicted to encode proteins that differ in functional activity and could represent novel determinants of virulence. To identify such proteins, we undertook a comparative...

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PMID: 23383074
DOI: 10.1371/journal.pone.0055120
PMCID: PMC3561388

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