Article
Base-calling algorithm with vocabulary (BCV) method for analyzing population sequencing chromatograms.
PloS one - 1 Jan 2013
Fantin Yuri S, Neverov Alexey D, Favorov Alexander V, Alvarez-Figueroa Maria V, Braslavskaya Svetlana I, Gordukova Maria A, Karandashova Inga V, Kuleshov Konstantin V, Myznikova Anna I, Polishchuk Maya S, Reshetov Denis A, Voiciehovskaya Yana A, Mironov Andrei A, Chulanov Vladimir P
Abstract excerpt
Sanger sequencing is a common method of reading DNA sequences. It is less expensive than high-throughput methods, and it is appropriate for numerous applications including molecular diagnostics. However, sequencing mixtures of similar DNA of pathogens with this method is challenging. This is important because most clinical samples contain such mixtures, rather than pure single strains. The traditional solution is...
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