Article
Whole genome composition distance for HIV-1 genotyping.
Computational systems bioinformatics. Computational Systems Bioinformatics Conference - 1 Jan 2006
Wu Xiaomeng, Goebel Randy, Wan Xiu-Feng, Lin Guohui
Abstract excerpt
Existing HIV-1 genotyping systems require a computationally expensive phase of multiple sequence alignments and the alignments must have a sufficiently high quality for accurate genotyping. This is particularly a challenge when the number of strains is large. Here we propose a whole genome composition distance (WGCD) to measure the evolutionary closeness between two HIV-1 whole genomic RNA sequences, and use that...
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