Article

Target-enriched sequencing enables genomic characterization within diverse microbial populations – a preprint

2025-10-24

Abstract excerpt

Characterizing microbial genetic sequences and key variants is critical for understanding pathogen ecology, transmission, and clinical impact. Yet, conventional metagenomic sequencing often yields too few on-target reads to move beyond species-level identification. We developed a target-enriched (TE) metagenomic workflow, including bait design, an optimized TE shotgun protocol, and the VARIANT++ pipeline, to recov...

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Identifiers and source

Literature Corpus work: 494286bd-3e93-5ffd-b4d5-4507e4afffc5
DOI: 10.1101/2025.10.23.684174

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