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Article

Extracellular ATP and Toll-like receptor 2 agonists trigger in human monocytes an activation program that favors T helper 17.

PloS one - 1 Jan 2013

Paustian Christopher, Taylor Patricia, Johnson Terrence, Xu Min, Ramirez Nancy, Rosenthal Kenneth S, Shu Suyu, Cohen Peter A, Czerniecki Brian J, Koski Gary K

Abstract excerpt

Strategically-paired Toll-like receptor (TLR) ligands induce a unique dendritic cell (DC) phenotype that polarizes Th1 responses. We therefore investigated pairing single TLR ligands with a non TLR-mediated danger signal to cooperatively induce distinct DC properties from cultured human monocytes. Adenosine triphosphate (ATP) and the TLR2 ligand lipoteichoic acid (LTA) selectively and synergistically induced...

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Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

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Source

Open in PubMed Open full text

Identifiers

PMID: 23382974
DOI: 10.1371/journal.pone.0054804
PMCID: PMC3561418

Genes

TLR2
LTA
CCR7
TLR4

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 6 Sept 2026. Manifest publication-graph-cohort-2026-09-06.1.

Source receipt: pubmed, retrieved 6 Sept 2026.

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