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Article

Periodontitis-associated pathogens P. gingivalis and A. actinomycetemcomitans activate human CD14(+) monocytes leading to enhanced Th17/IL-17 responses.

European journal of immunology - 1 Sept 2016

Cheng Wan-Chien, van Asten Saskia D, Burns Lachrissa A, Evans Hayley G, Walter Gina J, Hashim Ahmed, Hughes Francis J, Taams Leonie S

Abstract excerpt

The Th17/IL-17 pathway is implicated in the pathogenesis of periodontitis (PD), however the mechanisms are not fully understood. We investigated the mechanism by which the periodontal pathogens Porphyromonas gingivalis (Pg) and Aggregatibacter actinomycetemcomitans (Aa) promote a Th17/IL-17 response in vitro, and studied IL-17(+) CD4(+) T-cell frequencies in gingival tissue and peripheral blood from patients with...

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Identifiers

PMID: 27334899
DOI: 10.1002/eji.201545871
PMCID: PMC5031191

Genes

TLR2
TLR4
TNF

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 6 Sept 2026. Manifest publication-graph-cohort-2026-09-06.1.

Source receipt: pubmed, retrieved 6 Sept 2026.

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