Article
Deficiency of α-1-antitrypsin influences systemic iron homeostasis.
International journal of chronic obstructive pulmonary disease - 1 Jan 2013
Ghio Andrew J, Soukup Joleen M, Richards Judy H, Fischer Bernard M, Voynow Judith A, Schmechel Donald E
Abstract excerpt
There is evidence that proteases and antiproteases participate in the iron homeostasis of cells and living systems. We tested the postulate that α-1 antitrypsin (A1AT) polymorphism and the consequent deficiency of this antiprotease in humans are associated with a systemic disruption in iron homeostasis. Archived plasma samples from Alpha-1 Foundation (30 MM, 30 MZ, and 30 ZZ individuals) were analyzed for A1AT,...
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