Article
Genetic determinants of amidating enzyme activity and its relationship with metal cofactors in human serum.
BMC endocrine disorders - 15 Jul 2014
Gaier Eric D, Kleppinger Alison, Ralle Martina, Covault Jonathan, Mains Richard E, Kenny Anne M, Eipper Betty A
Abstract excerpt
BACKGROUND: α-amidation is a final, essential step in the biosynthesis of about half of all peptide hormones and neurotransmitters. Peptidylglycine α-amidating monooxygenase (PAM), with enzymatic domains that utilize Cu and Zn, is the only enzyme that catalyzes this reaction. PAM activity is detected in serum, but its significance and utility as a clinical biomarker remain unexplored. METHODS: We used...
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