Article
Genetic differences in Native Americans and tacrolimus dosing after kidney transplantation.
Transplantation proceedings - 1 Jan 2000
Chakkera H A, Chang Y-H, Bodner J K, Behmen S, Heilman R L, Reddy K S, Mulligan D C, Moss A A, Khamash H, Katariya N, Hewitt W R, Pitta T L, Frassetto L A
Abstract excerpt
Tacrolimus pharmacokinetics vary due to single nucleotide polymorphisms (SNPs) in metabolizing enzymes and membrane transporters that alter drug elimination. Clinically we observed that Native Americans require lower dosages of tacrolimus to attain trough levels similar to Caucasians. We previous...
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