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Article

The effect of LDLR-negative genotype on CT coronary atherosclerosis in asymptomatic statin treated patients with heterozygous familial hypercholesterolemia.

Atherosclerosis - 1 Apr 2013

Ten Kate Gert-Jan R, Neefjes Lisan A, Dedic Admir, Nieman Koen, Langendonk Janneke G, Galema-Boers Annette J, Roeters van Lennep Jeanine, Moelker Adriaan, Krestin Gabriel P, Sijbrands Eric J, de Feyter Pim J

Abstract excerpt

OBJECTIVE: To evaluate the influence of LDL receptor (LDLR) -negative mutational status on CT coronary atherosclerosis in asymptomatic statin treated patients with heterozygous familial hypercholesterolemia (FH). METHODS: Coronary CT angiography (CCTA) was performed in 145 FH patients (93 men; mean age 52 ± 8) screened for LDLR and apolipoprotein B (APOB) mutations. The extent of coronary plaque was compared...

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Share to Apolipoproteins B
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Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

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Share to Hydroxymethylglutaryl-CoA Reductase Inhibitors

Share to Hyperlipoproteinemia Type II

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Source

Identifiers

PMID: 23369702
DOI: 10.1016/j.atherosclerosis.2012.12.016

Genes

LDLR
APOB

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 5 Sept 2026. Manifest publication-graph-cohort-2026-09-05.1.

Source receipt: pubmed, retrieved 5 Sept 2026.

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