Article
Impaired cytoplasmic-nuclear transport of hypoxia-inducible factor-1α in amyotrophic lateral sclerosis.
Brain pathology (Zurich, Switzerland) - 1 Sept 2013
Nagara Yuko, Tateishi Takahisa, Yamasaki Ryo, Hayashi Shintaro, Kawamura Mami, Kikuchi Hitoshi, Iinuma Kyoko Motomura, Tanaka Masahito, Iwaki Toru, Matsushita Takuya, Ohyagi Yasumasa, Kira Jun-ichi
Abstract excerpt
We investigated the mechanisms underlying abnormal vascular endothelial growth factor (VEGF) production in amyotrophic lateral sclerosis (ALS). We immunohistochemically studied VEGF, its receptors VEGFR1 and 2, and hypoxia-inducible factor-1α (HIF-1α) in autopsied ALS spinal cords. We also chronologically assessed the expression of HIF-1α, karyopherin β1, karyopherin β-cargo protein complex inhibitors and nuclear...
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