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Article

Ibuprofen inhibits colitis-induced overexpression of tumor-related Rac1b.

Neoplasia (New York, N.Y.) - 1 Jan 2013

Matos Paulo, Kotelevets Larissa, Goncalves Vania, Henriques Andreai F A, Henriques Andreia, Zerbib Philippe, Moyer Mary Pat, Chastre Eric, Jordan Peter

Abstract excerpt

The serrated pathway to colorectal tumor formation involves oncogenic mutations in the BRAF gene, which are sufficient for initiation of hyperplastic growth but not for tumor progression. A previous analysis of colorectal tumors revealed that overexpression of splice variant Rac1b occurs in aroun...

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Share to Prostaglandin-Endoperoxide Synthases
Share to Cell Transformation, Neoplastic
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Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

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Source

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Identifiers

PMID: 23359345
DOI: 10.1593/neo.121890
PMCID: PMC3556943

Genes

BRAF

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 4 Sept 2026. Prepared record publication-23359345-2026-09-04.2. Manifest publication-graph-cohort-2026-09-04.2.

Source receipt: PubMed via Helena Literature Corpus, retrieved 4 Sept 2026.

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