Article
Fast and accurate read mapping with approximate seeds and multiple backtracking.
Nucleic acids research - 1 Apr 2013
Siragusa Enrico, Weese David, Reinert Knut
Abstract excerpt
We present Masai, a read mapper representing the state-of-the-art in terms of speed and accuracy. Our tool is an order of magnitude faster than RazerS 3 and mrFAST, 2-4 times faster and more accurate than Bowtie 2 and BWA. The novelties of our read mapper are filtration with approximate seeds and a method for multiple backtracking. Approximate seeds, compared with exact seeds, increase filtration specificity...
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