ACCUSA2: multi-purpose SNV calling enhanced by probabilistic integration of quality scores.

Abstract excerpt

SUMMARY: Direct comparisons of assembled short-read stacks are one way to identify single-nucleotide variants. Single-nucleotide variant detection is especially challenging across samples with different read depths (e.g. RNA-Seq) and high-background levels (e.g. selection experiments). We present ACCUSA2 to identify variant positions where nucleotide frequency spectra differ between two samples. To this end,...

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