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Article

Cancer risk in a cohort of subjects carrying a single mismatch repair gene mutation.

Familial cancer - 1 Jan 2009

Stupart D A, Goldberg P A, Algar U, Ramesar R

Abstract excerpt

Hereditary non-polyposis colon cancer (HNPCC) is an autosomal dominant condition, caused by germline mutations in the mismatch repair genes, that presents with colorectal cancers at a young age, as well as extracolonic tumours. One of the causative mutations is the C1528T (Exon 13) mutation of the MLH1 gene. The purpose of this study is to document the cancer risk for subjects who carry this mutation. This is a...

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Source

Identifiers

PMID: 19688281
DOI: 10.1007/s10689-009-9281-5

Genes

MLH1

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 5 Sept 2026. Manifest publication-graph-cohort-2026-09-05.1.

Source receipt: pubmed, retrieved 5 Sept 2026.

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